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Complete Fully Automated Imaging System for High Resolution 3D Datasets 

Acquire 3D datasets from detailed 2D sections with High Resolution Episcopic Microscopy(HREM). This 3D microscopy technique is designed to give volume datasets from imaging the block face of resin prepared samples using a custom imaging system.

Complete 3D imaging system inclusive of software and hardware

Clean 1 micron sectioning using a custom designed microtome for serial block face imaging

Compatible with a range of block face imaging techniques including HREM (High-Resolution Episcopic Microscopy)

High quality, high resolution images of morphology in dense and soft tissue, without sample clearing. 

Benefits of High Resolution Episcopic Microscopy

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Flexibility for a Range of Samples

High-Resolution Episcopic Microscopy (HREM) delivers exceptional clarity and resolution, even when imaging denser tissues or tissues with varying opacities.


Unlike conventional techniques, High-Resolution Episcopic Microscopy (HREM) eliminates the need for tissue clearing, making the imaging process more efficient and convenient.HREM produces high-contrast results, enhancing the visualization of anatomical structures and details.

HREM (High Resolution Episcopic Microscopy) Embryo Heart 3D
HREM Imaging System XY Scan

High Resolution for All Tissue Types

High-Resolution Episcopic Microscopy (HREM) offers a variety of resolutions with scanning stages and a choice of optics. It can capture single shots or high-resolution scans at 100x magnification with blending, no blocking.


With sections as thin as 1 µm, from our speciality section system, HREM achieves voxel resolutions of 1-8 µm³, enabling the identification of fine details like individual nerves and blood vessels, surpassing other techniques like OPT, µMRI, or µCT.

HREM (High Resolution Episcopic Microscopy) Mouse Embryo Imaging

HREM Easy Data

High Resolution Episcopic Microscopy (HREM) data is readily applicable for both 2D and 3D analysis. Simple software packages like Fiji and Dragonfly can be used to generate impressive images by inverting the LUT (Lookup Table). High-Resolution Episcopic Microscopy (HREM) images can be manually segmented, owing to their user-friendly 2-Dimensional format, enabling precise measurement of specific features.

Applications for HREM

High Resolution Episcopic Microscopy (HREM) is used in the study of mouse organs (such as brains and hearts) whole mouse embryos or even plantsAs the field of HREM continues to expand, new research papers emerge each year, showcasing the potential in different applications.


Integrate High-Resolution Episcopic Microscopy (HREM) into your research, gaining a valuable tool in your workflow. Explore the accomplishments of our satisfied HREM customers by delving into their published papers.


"HREM data has allowed the DMDD team to identify nearly 400 different phenotypes in knockout mouse embryos. These range from large-scale organ malformations to the abnormal development of nerves and blood vessels."

Tim Mohan

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